Karyotekk Services
Stem Cell and Cell Line Karyotyping for Genomic Instability
Karyotekk Inc. offers a service designed for the assessment of genomic instability and the detection of chromosomal abnormalities across various animal cell types, such as stem cells, embryos, and cell lines. By implementing detailed chromosome number counting and high-resolution karyotyping, we can identify both structural rearrangements and numerical anomalies that may suggest underlying genetic disorders, developmental abnormalities, or cell line stability issues. The insights gained from this analysis are essential for enhancing therapeutic and regenerative medicine strategies, directing reproductive genetic initiatives, and bolstering veterinary diagnostics and research endeavours.
Standard analysis includes a comprehensive review of metaphase spreads and complete karyotypes, with the option for customization tailored to specific project needs. Our service provides reliable, actionable results for breeders, researchers, clinicians and veterinarians.
Genetic Screening for Abnormalities Effecting Animal Fertility
Karyotekk Inc. specializes in providing species-specific karyotyping services utilizing cutting-edge techniques such as G-band, C-band, and FISH analysis. Our primary offerings include targeted diagnostics for pigs, horses, and cattle, with the option for additional testing across a variety of domestic and wild species upon request. We have the capability to identify chromosomal abnormalities that may influence fertility, reproduction, and the overall health of herds.
Moreover, our expertise encompasses a broad spectrum of both domestic and wild species, including cats, sheep, goats, bison, gaur, and muskox. We deliver vital information regarding inherited or spontaneous genetic abnormalities that could affect productivity and animal well-being. Our commitment to advancing animal health through precise cytogenetic insights makes us a reliable partner in the field of veterinary genetics.
In pigs, G-band karyotyping can identify structural rearrangements such as chromosome translocations, which may affect up to 2% of the population and are a significant cause of infertility. In horses, sex chromosome aneuploidies, including XO and XXY stallions, can be diagnosed through G-band and FISH analysis. For cattle, G-band testing reveals both structural and sex chromosome abnormalities that may hinder reproductive success. Our karyotyping service delivers comprehensive profiling for intricate genetic investigations, providing precise and actionable insights that support livestock management, veterinary diagnostics, and reproductive research.
Standard analysis includes a comprehensive review of 2-5 complete karyotypes, with the option for customization tailored to specific project needs.
Intersex Diagnosis
Karyotekk Inc. provides advanced animal karyotyping services tailored for clients interested in thorough genetic analysis. Our services cover conditions that may influence reproductive outcomes, including intersex traits, sex reversal, and freemartins, which are crucial for optimizing breeding strategies and enhancing herd productivity. Our testing solutions are well-suited for veterinary diagnostics, breeding programs, and reproductive health research.
We diagnose intersex conditions caused by chromosomal mutations, confirm genetic sex in cases of sex reversal, and identify freemartinism in cattle, sheep, and goats amongst other species. We have identified several cases of androgen insensitivity syndrome (AIS) in horses, which is a genetic disorder where XY individuals appear female and are infertile. Our karyotyping service delivers accurate results and tailored reporting to support informed decision-making in animal health management, fertility evaluation, and genetic carrier detection.
Our expertise extends beyond standard genetic assessments, providing comprehensive analysis that contributes to improved breeding programs and animal welfare. We utilize advanced cytogenetic techniques to ensure the accuracy of our findings, enabling veterinary professionals and breeders to make informed choices in their practices. By identifying genetic anomalies and understanding their implications, we help to enhance overall herd health and productivity.
Standard analysis includes a comprehensive review of 2-5 complete karyotypes, with the option for customization tailored to specific project needs.
1/29 Translocation Test
At Karyotekk Inc., our expert team is dedicated to providing detailed results with fast turnaround times, supporting clients in veterinary diagnostics, breeding programs, and animal genetics research. Our service provides accurate detection of chromosomal abnormalities that impact fertility, development, and herd productivity.
One key application to our service is screening for the 1/29 chromosomal translocation in Bos taurus cattle, which is a heritable abnormality linked to reduced reproductive efficiency. Affected cattle experience approximately a 10% drop in fertility, increasing return-to-service rates, longer calving intervals, and higher culling rates. Routine karyotype testing helps identify carriers, enabling selective breeding strategies that improve herd fertility. Karyotekk Inc. applies a specialized diagnostic procedure for detecting the 1/29 translocation, providing producers with a valuable tool for genetic screening and herd management.
Standard analysis includes a comprehensive review of 20 metaphase spreads and the addition of 2 karyotypes when required, with the option for customization tailored to specific project needs.
Related Articles
Dain, A., Dott, H., Newcomb, R., & Schwabe, A. (1985). Cytogenetic studies of 1–29 translocation carrying cows and their embryos. Theriogenology, 23(4), 641–653.
Rezaei, S., Donaldson, B., Villagomez, D. A. F., Revay, T., Mary, N., Grossi, D. A., & King, W. A. (2020). Routine karyotyping reveals frequent mosaic reciprocal chromosome translocations in swine: prevalence, pedigree, and litter size. Scientific Reports, 10(1).
Villagómez, D. A., Iannuzzi, L., & King, W. A. (2012). Preface. Sexual Development, 6(1–3), 5–6.